The interconnecting interactions of crystallographic slip systems across ensembles of grains have been posited to be a critical factor in stress localization and subsequent nucleation of damage. To test these hypotheses, quantitative methods are needed to characterize slip activity in-situ in the bulk of deforming polycrystals. Here we present a new methodology that combines measurements of grain average stresses and spatially-resolved lattice orientation fields gathered using high-energy X-ray diffraction microscopy (HEDM) with crystal plasticity kinematics to reconstruct full 3-D slip activity fields at micron-scale resolutions. The utility of the method will be demonstrated through analysis of slip activity in Ti-7Al deformed under uniaxial tension. Focus will be placed on exploring stress dependence, lattice orientation dependence, and connectivity (network relationships) of grains experience elevated amounts of slip.