Shock compression studies for analyzing materials with real world applications typically use material fresh from the manufacturer; however, over time, these materials experience harsh conditions during use which may alter their mechanical response. In particular, cyclic fatigue is known to generate damage which can noticeably degrade mechanical behavior under quasi-static loading. Here, the Hugoniot elastic limits and spall strengths of alpha Fe samples fatigued under different loading cycles are probed using a series of in-situ spall experiments performed at the light gas gun facility at the U.S. Army Research Laboratory. Despite the expectation of the fatigued samples to exhibit damage dependent mechanical behaviors under quasi-static and comparatively low rate dynamic loading, the Hugoniot elastic limits and spall strengths of the fatigued, high purity alpha Fe specimens appear to be damage independent.