The remarkable crystallographic plastic anisotropy, tension-compression asymmetry and strong texture effects in low symmetry hexagonal close-packed (HCP) materials are often referred to as origins of damage intolerance. While post-mortem experimental evidence indicates ductile processes at play, the role of anisotropic slip and twinning on the rates and states of damage accumulation remains elusive. In this talk, we present the micromechanics of void evolution in HCP materials using three-dimensional, finite element crystal plasticity unit cell calculations. Emergent interactions between void growth with deformation mechanisms leading to void coalescence are discussed with implications on the damage tolerance of technologically important HCP alloys. The investigation provides insight for improved descriptions of continuum damage models.