Plastic-bonded explosive (PBX) 9502 is produced as a molding powder comprised of 95wt% 2,4,6-triamino-1,3,5-trinitrobenzene (TATB) and 5wt% Kel-F-800TM. Three-dimensional (3D) microstructures can be achieved by varying compaction and sintering approaches on the powder. However, studies have suggested that the PBX9502 3D microstructure and shock sensitivity are correlated without having an understanding of the mechanisms responsible for generating detonation hotspots. This has important ramifications from a safety and performance perspective. In this work, we synthesize two different 3D microstructures of 1 mm3 PBX 9502. In the first method, PBX 9502 samples are uniaxially die pressed with a single round of thermal cycling to reach ~2.4% porosity and with the TATB polycrystals and pores oriented in the direction of compression. Conversely, in the second method, PBX 9502 samples are made isotropic with ~3.4% porosity after isostatic compression with two rounds of thermal cycling. We perform in situ x-ray phase contrast imaging in the Dynamic Compression Sector at the Advanced Photon Source of the PBX 9502 samples to visualize their failure as they are uniaxially compressed at strain rates of up to 103 s-1 using a PDV-based Kolsky bar apparatus (Bryan Zuanetti will be elaborating on the design of the Kolsky bar in the same session). I will discuss a Fourier-based image analyses that we develop to compare and correlate the failure behavior of PBX 9502 to its 3D microstructure and the loading direction. In the analyses, a simple method is introduced to provide relative measures of crack orientation distribution and a model-based approach in an attempt to provide absolute measures of 3D crack size and orientation distribution. These types of calculations will be invaluable for improving modeling of energetic materials to increase our understanding of hot spot formation.