The Laser-Induced Particle Impact Test (LIPIT) can be used to probe projectile, target, and synergistic projectile-target responses to high strain rate deformation at the microscale. LIPIT’s advantages over other microscale launching techniques include the ability to controllably launch a single microparticle and precisely characterize the projectile momentum and kinetic energy before and after target impact. Hence, LIPIT experiments have been used to study the dynamic response of many polymers, gels, and metals in different structural forms. These microscopic high-rate deformation behavior and impact energy absorption studies were used to suggest promising materials for macroscopic applications. Geometric scale, however, can significantly influence dynamic material behavior through scale-induced changes in event time, strain rate, material homogeneity, and more. In this updated study, such scale effects are investigated in more detail. Alumina spheres ranging five orders of magnitude in diameter (3 μm to 10 mm) were launched into scaled amorphous polycarbonate targets at normal incidence using either LIPIT or a gas gun. Projectile impact velocity and the projectile diameter to target thickness ratio were held constant in all experiments (550 m/s and 0.25, respectively). Impact energies spanned from hundreds of joules down to nanojoules. The specific impact energy absorption, local plastic deformation, and deformation microstructure were compared across all scales. Length scale reduction sets in motion a remarkable 230% amplification in specific energy absorption and a 240% increase in relative impact deformation area. Corresponding numerical impact simulation results emphasize key limitations of current continuum-based material models and indicate potential areas of improvement. These findings demonstrate that material property discoveries made using emerging high-throughput methods may not be directly indicative of macroscopic behavior and performance.